ANTIDIABETIC AND HEPATOPROTECTIVE EFFECTS OF COMBINED AQUEOUS LEAF EXTRACT OF Azadirachta indica AND Mangifera indica IN ALLOXAN MONOHYDRATE-INDUCED DIABETIC WISTAR RATS

This study was aimed at assessing the antidiabetic and hepatoprotective effects of combined aqueous leaf extract Azadirachta indica Mangifera in alloxan monohydrate-induced diabetic Wistar rats. Fresh leaves were prepared using distilled water appropriate stock concentrations used a 14-day treatment. Acute toxicity studies conducted rats showed no up to 5000mg/kg. Experimental animals acclimatized for 14 days while diabetes induced monohydrate (150mg/kg) intraperitoneally. After treatment with 300mg/kg, 500mg/kg 700mg/kg respectively as well 150mg/kg metformin, there increase weight, blood glucose levels decreased significantly (p<0.05) whenc compared untreated (diabetic control). Also, significant p<0.05) reduction serum aspartate aminotransferase (AST), alanine (ALT) alkaline phosphatase (ALP) treated different doses control. A dose dependent hepatoprotecitve effect observed had close similar standard drug metformin. Therefore, exhibit this is due presence phytochemical constituents part plants. KEY WORDS: indica, extract, diabetes, hepatotoxicity, Bioactive